Bond follows his target through the parade as Sciarra quickly calls someone to pick him up in the square. Sciarra gets on to a descending helicopter and climbs in as Bond catches up and beats Sciarra's goons before jumping in the helicopter with him. As it takes off, Bond fights both Sciarra and the pilot. The helicopter flies dangerously close to the innocent people taking part in the parade as Bond tries to kill his target.
Bond runs into Moneypenny (Naomie Harris) and she demands to know how reason and he shows her the reason he went after Sciarra: the previous M (Judi Dench) has sent him a tape shortly after her death, instructing Bond to find Sciarra, kill him, and go to the funeral in Rome. Moneypenny also gives Bond a box of items recovered from Skyfall. Bond looks in the box and sees, among other things, a picture of a man and a boy, with a third person's face burnt out of the picture.
Bond rides around the river with Bill Tanner (Rory Kinnear) where they get a glimpse of the new JIS building. Tanner says that C's plan is to create "Nine Eyes", a program that will allow access to intelligence streams in nine countries. The new Nine Eyes program will also decommission the 00 program because they claim it is unnecessary and obsolete with their new electronic surveillance methods.
Bond arrives in Rome with the Aston Martin for Sciarra's funeral. He encounters Sciarra's widow Lucia (Monica Belucci). At night, in her home, Lucia is nearly executed by two men until Bond shows up and gets them first. Despite knowing that Bond killed her husband, she gave in to his seduction and informs him of the organization that Sciarra was part of.
Bond arrives at the hideout of this organization by using the octopus ring as entry. There, he enters a balcony and observes a large number of people at a boardroom table discussing events in Marrakesh and Tunisia, as well as the planned bombing in Mexico. A man cloaked in shadows (Christoph Waltz) enters and oversees the meeting. They also mention The Pale King and plan to get rid of him. He calls upon a man to be the muscle in their plans, but a much larger fellow, Mr. Hinx (Dave Bautista), steps in for consideration. Hinx slams the man's head on the table and plunges his thumbs into the man's eyes after which the first man falls to the floor. Hinx wipes the blood off his fingers with a handkerchief and assumes the role of the main henchman.
Moneypenny informs Bond that The Pale King is really Mr. White (Jesper Christensen), (the same shadowy middleman from the crime organization Quantum from two previous Bond films 'Casino Royale' and 'Quantum of Solace') while she learns that Oberhauser and his father were reported to have died in an avalanche.
Bond finds White's daughter, Dr. Madeleine Swann (Lea Seydoux) at the clinic high in the Austrian alps. She asks him some test questions before he tells her that he watched her father kill himself. Madeleine orders him to leave and angrily walks away from Bond outside the building before she is captured by Hinx and his fellow goons. Bond takes a plane and chases the villains, eventually causing them to crash their cars before he rescues Madeleine, leaving only Hinx alive.
Bond brings Madeleine to meet with Q, who has done an analysis on the ring. It contains files which reveal that Bond's most recent enemies (Mr. White, Sciarra, Le Chiffre, Dominic Greene, and Raoul Silva) were all connected to Oberhauser, and that other organizations like Quantum were subsidiaries of this organization. Madeleine says that the organization's name is Spectre, and that L'Americain is not a person as Bond had originally believed, but a hotel in Morocco.
Meanwhile in London, M has learned that Bond has left the country against his orders. He must also deal with C initiating Nine Eyes, though the decision to launch it must be unanimous, and C has at least one detractor. The 00 program is also officially shut down.
Bond and Madeleine travel to Tangier and locate the L'Americain Hotel. Bond sees a mouse run into a hole in the wall and suspects that there might be something behind the wall. Bond punches out the wall and finds a hidden room adjacent to their hotel room. They find a stash of tapes and pictures kept by Mr. White that lead to the next clue in where to find Spectre.
The train stops at an isolated station in the middle of nowhere and are picked up by a man in an old Rolls Royce. They are driven to the Spectre facility in a meteor crater in this very isolated part of the desert. Oberhauser and his men find Bond and Madeleine, where Oberhauser states that he is the mastermind behind every painful event over the last few years of Bond's life. He brings up Vesper Lynd's death, as well as the last M's death. He then pulls up a video of Bond's last meeting with White, showing him passing the gun to White before his death, proving the incredible reach of their new surveillance technology. It is also revealed that C works under Oberhauser, and Nine Eyes will give Spectre access to all the intelligence streams. Bond then gets knocked out by a thug.
Bond wakes up strapped in a chair, prepped for torture. Oberhauser tells Madeleine how his father looked after Bond after the death of Bond's parents, and he was something of a brother to Bond until he faked his death in the avalanche. Now, he is no long Oberhauser, but really...Ernst Stavro Blofeld - his old nemesis (from the days of Sean Connery's Bond movies). Blofeld turns on robotic, high speed little drills that drill into Bond's head. Madeleine approaches him and admits her love for him. Bond slips her his watch, that Q gave him, and sets the timer. Knowing what's happening, she slides the watch toward Blofeld as it explodes and unlocks the torture chair. Bond and Madeleine escape, after a firefight with henchmen. The facility is destroyed by gigantic explosions as they leave the crater.
Bond returns to London to join Tanner, Q, and Moneypenny as C is arrested. Madeleine leaves Bond because she wants no part in the life he leads. The heroes are ambushed, and Bond is taken.
Bond is taken to the former MI6 building and quickly takes out his captors. He finds Blofeld, now blind in his right eye and sporting his trademark scar. Blofeld says that Madeleine is in the building, which is set to explode. Meanwhile, M and the others attempt to relocate C and stop Nine Eyes from launching. M finds C in his office and tricks the villain into officially disabling the program. C fights M and tries to shoot him, but M causes him to shoot the glass ceiling, throwing C off-balance and causing him to fall over the balcony to his death.
Bond finds Madeleine and escapes with her on a boat over the Thames River as the building is destroyed - collapsed by multiple charges detonated simultaneously. Blofeld is escaping on a helicopter, but Bond manages to shoot him down. The helicopter crashes onto a bridge over the Thames River and is surrounded by police. Blofeld is apprehended by M while Bond leaves with Madeleine.
The film ends with Bond asking Q for one last favor: the vintage Aston Martin from the earliest Bond films, which we glimpse under restoration early in "Spectre". He and Madeleine drive off in the silver sports car into London traffic.